Healthcare & Biotech Startups in California

California

California

Palo Alto, CA

Patients endure anxiety in the waiting room, confusion at the front desk, and long delays when they need help most, while clinicians are stretched thin by chronic staffing shortages, outdated...

San Francisco, California

Surgical soft tissue repairs often fail as sutures cut through tissue or mesh at anchor points, causing pain, dehiscence, hernia recurrence, and reoperations.

San Francisco, CA

Clinical trials struggle to find and enroll eligible patients quickly; lengthy enrollment timelines and high costs.

California

Large number of lost or stolen handguns annually (500k–700k). Everyday carry increases risk of loss/theft ~300x. Lost/stolen guns are often used in crime.

Laguna Niguel, California

Ultrasound probe, imaging equipment, parts and repair purchasing runs through fragmented channels (brokers, emails, PDFs, spreadsheets), making model-specific sourcing slow for buyers and limiting...

Los Angeles, CA

Potential investment opportunities

Menlo Park, CA

General Inception is a deep-tech venture studio ("Igniter") that co-founds and builds life sciences companies across Engineered Biology, Life Science Tools & Diagnostics, and Therapeutics. They...

Pacific Palisades, California

Repeat purchase consumable category businesses with differentiated IP or defensible manufacturing/vertical integration; typically invests at 1000000-5000000 revenue, targets 5-10% equity, takes...

Los Angeles, CA

Founded in 1999, JUMP Investors is a venture capital firm based in Los Angeles, California. The firm seeks to make investments in sectors like information technology, healthcare, media, and...

Palo Alto, CA

Seed-stage, US-focused software & internet investors who emphasize diversity and decision-analysis driven diligence; target high-conviction founders in enterprise software, fintech, digital health,...

Palo Alto, California

K2X is a Silicon Valley-based FinTech offering global investors a novel, safer, higher-return, non-correlated, diversified, and liquid (assuming NASDAQ IPO completed) way to invest in the best...

San Francisco, CA

Deep tech venture studio that partners as a business co-founder with scientific founders to translate foundational science into companies across engineered biology, life science tools & diagnostics,...

Atherton, CA

Founded in 2010, PivotNorth Capital is a venture capital firm based in Atherton, California. The firm prefers to invest in wages, housing, banking, transportation, food, internet access, education,...

Los Angeles, CA

Stage Venture Partners is a pre-Seed and Seed stage venture capital firm that invests in emerging enterprise software technology for B2B markets across North America. They focus on recurring revenue...

San Francisco, CA

Invests early in founders building at the frontiers of science: healthcare, genomics, machine intelligence, aerospace and new chemistries.

Palo Alto, CA

VVP invests in US-based, early-stage software and deep-tech startups building focused solutions for specific industry verticals. They prioritize founder-market fit rooted in years of operating...

Los Angeles, CA

We invest early in technical teams transforming major industries — healthcare, logistics, real estate, manufacturing and other essential industries where technical innovation can solve critical...

Palo Alto, CA

SparkLabs Group is a global network of startup accelerators and venture capital funds founded in 2013. With presence across the U.S., Europe, and Asia, they have invested in 500+ startups across six...

San Francisco, CA

Generalist investor with data-driven sourcing; uses a proprietary data platform to find early teams.

San Francisco, CA

Invests in capital-efficient HealthTech startups (seed and Series A) focused on improving healthcare delivery and lowering costs. Target areas include digital health, medical devices, diagnostics,...

Los Angeles, CA

Opportunities for investment with possibility of hands on involvement. Ideal founder: Subject matter expert with history of innovation and sales expertise.

California

Investing in hard technology — chemistry and materials innovations, medical devices, life sciences, sustainability and energy. CAN Fund I invests up to $150K in early-stage startups; geography...

San Francisco, CA

SV Angel is a San Francisco-based venture fund investing broadly in software-focused consumer and enterprise companies. Composed of an early-stage Seed Fund (typical seed check ~$200k) and a Growth...

San Francisco, CA

Rock Health is a venture capital firm investing in digital health start-ups.

Los Angeles, CA

Industry-agnostic venture firm investing from pre-seed to Series A. Hands-on, value-add approach with bespoke accelerators (NextUp), programs, and strategic partnerships. Typical direct checks up to...

Menlo Park, CA

Partnering with ambitious early-stage founders building category-defining companies; focus on early-stage consumer and enterprise opportunities across North America.

San Francisco, CA

LAUNCH backs founders at very early stages through a mix of accelerator, founder education, direct fund investments and a large public syndicate. They target high-velocity early-stage technology...

Palo Alto, CA

Creating an ETF-like vehicle of diversified, double-vetted early-stage startups. Focused on top <10% founders primarily in Life Sciences and Technology (Seed and Series A). Agnostic to geography...

Bakersfield, CA

Industry-agnostic early-stage to Series B investor focused on companies that positively impact Kern County and the Central Valley; leverages local strengths in aerospace, energy, agriculture,...

Menlo Park, CA

Nexus Venture Partners is a venture capital firm partnering with product-first entrepreneurs, focused on enterprise software companies in the US and digitally-powered businesses in India. The firm...

San Francisco, CA

Founded in 2010, AngelPad is a seed-stage accelerator based in San Francisco and New York. We select ~15 teams every 6 months and invest $120,000 in each company. We focus on early-stage startups...

San Francisco, CA

Seed and pre-seed investors focused on companies that build network effects across Bio, Gaming, Generative AI, PropTech, Space, FinTech, Marketplaces, and Crypto. We prioritize founding team quality...

Santa Monica, CA

Founded in 1996, Upfront Ventures is a venture capital investment firm based in Santa Monica, California. The firm prefers to invest in companies operating in the commercial services, software,...

Campbell, CA

Early-stage investments focused on enterprise software, SaaS, IT services and enterprise AI; active manager of an early-stage venture fund and occasional balance-sheet investments where they can add...

Menlo Park, CA

A globally minded, tech-centric venture firm investing at the intersection of enterprise, healthcare, and consumer opportunities. Focused on early-stage and growth opportunities enabled by...

San Mateo, CA

Wildcat Venture Partners invests in B2B and B2B2C startups leveraging Artificial Intelligence and Machine Learning to disrupt industrial sectors, with a focus on healthcare and the energy transition....

San Francisco, CA

Former operators investing in operators. We invest primarily in software companies from Pre-Seed to Series A. Areas of interest include B2B SaaS (especially unique verticals), bottoms-up SaaS,...

San Francisco, CA

Zero Shot Fund backs AI-native founders in the post-AGI era, leveraging OpenAI alumni experience to provide first-principles technical judgment and early access to ideas. They invest $2–5M at...

Santa Monica, CA

Early-stage (seed and Series A) venture capital firm investing in visionary founders building disruptive software businesses across work, health, commerce, and money, with a focus on enabling...

Los Angeles, CA

Time BioVentures is a life sciences and healthcare venture capital firm based in Southern California. The firm seeks to invest in life sciences and healthcare companies with a focus on therapeutics,...

San Francisco, CA

Early-stage, AI-first venture firm investing in Applied AI across Future of Work/Productivity, Mobility, Health, Financial Infrastructure, Digital Infrastructure, and Climate & Energy. Often leads...

Menlo Park, CA

Founded in 1961, Norwest Venture Partners is a venture capital and growth equity investment firm. The firm prefers to invest in early to later-stage companies in the United States, India, and Israel...

San Francisco, CA

Community-driven VC backing Harvard founders at the earliest stages (angel to seed). Sector-agnostic but leans into FinTech, HealthTech (digital health), AI, and B2B. Provides small checks and access...

San Francisco, CA

We invest in pre-seed B2B technology companies transforming foundational industries across the US-Mexico corridor, leveraging US technical innovation and Mexico's industrial strength to accelerate...

Sunnyvale, CA

Founded in 2006, Plug and Play Tech Center is an accelerator and incubator firm based in Sunnyvale, California. The firm prefers to invest in companies operating in advanced manufacturing, aerospace,...

Menlo Park, CA

IVP partners with breakout companies at inflection points, backing a small number of companies each year (primarily Series B / later-stage) and supporting rapid scale from millions to hundreds of...

San Francisco, CA

Pre-seed only: a generalist pre-seed fund that backs pre-revenue teams and has a fintech track record. Writes $500K–$3M checks and leads rounds.

Santa Monica, CA

Patron backs early-stage founders defining next-generation consumer technology through a gaming lens. Focused on Seed-stage investments across games, consumer internet, and Web3, leveraging...

Menlo Park, CA

Independent VC formed in partnership with NTT investing from seed through growth in enterprise and healthcare technology, with a focus on AI/ML, digital health, SaaS and enterprise infrastructure;...

Sacramento, California

Sacramento Angels is an angel group investing in early-stage companies throughout Northern California and beyond. Since 2000 they have invested in 100+ companies across B2B SaaS, enterprise software,...

Palo Alto, CA

Market-driven, thesis-based investing in founders solving large market pain points with demonstrated product-market fit; focus on consumer value proposition, superior design, and scalable opportunity.

Menlo Park, CA

Venture Funds and Operating System for Independent VC Professionals. Join as a Partner; apply to raise or recommend startups. Focus on companies on the market with revenue or lead investment from...

San Diego, CA

Mid-stage, community-oriented VC focused on propelling technology startups globally. Preference for software-enabled, capital-efficient B2B models (open to select B2C and HaaS). Typical first check...

Burlingame, CA

We invest in a small number of select founders and actively mentor them to achieve success. With 30+ years of experience founding and scaling startups, our team provides hands-on operational support,...

Menlo Park, CA

Partnering with founders from inception to IPO across enterprise software, AI, healthcare, fintech, infrastructure and transformative technology.