The Startup Scene in Missouri

Browse the Missouri startup ecosystem featuring 28 investors and startups. Our directory includes 27 angel investors and VCs with an average check size of $6.6M, plus 1 startups across all sectors. 1 investors are actively investing, and 0 startups are generating revenue.

27
Investors
1
Startups
$6.6M
Avg Check
0%
With Revenue
St. Louis
Top City
4%
Active Investors

Äggler

Harrison Reid

PRE SEED

Columbia, MO

IOT

Hobby farmers and backyard gardeners often neglect watering plants or monitoring animal infrastructure (e.g., electric fences, chicken coops) leading to stress and loss of animals/plants.

Product BuiltTechnical

AMERICAN CENTURY VENTURE FUND

AMERICAN CENTURY VENTURE FUND

VC

Kansas City, Missouri

Exploring

Stakehouse Fund I QP

Stakehouse Fund I QP

VC

Saint Louis, Missouri

Check: $300K – $1.5M
Exploring

Cultivation Capital AgTech Fund

Cultivation Capital AgTech Fund

VC

Saint Louis, Missouri

Check: $200K – $1.0M
Exploring

Cultivation Capital

Cultivation Capital

VC

St. Louis, MO

Check: $100K – $6.5M

Cultivation Capital is a venture capital firm managed by team of serial entrepreneurs. The firm's goal is to take revenue-generating businesses to the next level with help from the General Partners....

Exploring9 portfolio co.

OPENAIR Equity Partners

OPENAIR Equity Partners

VC

Kansas City, MO

Check: $1.0M – $105.0M
Exploring7 portfolio co.

proChain Ventures

proChain Ventures

VC

Saint Louis, MO

Check: $25K – $1.0M
LOGISTICS AND SHIPPINGSUPPLY CHAIN TOOLSIOT+7

proChain Ventures is a specialist venture capital firm investing in pre-seed and seed (pre-Series A) startups transforming global supply chains. Focus on supply-chain-related hard tech and deep tech...

Exploring18 portfolio co.

Build-A-Bear Workshop

Build-A-Bear Workshop

Corporate

Saint Louis, MO

Check: $2.7M – $10.3M

Build-A-Bear Workshop In

Exploring1 portfolio co.

Capital Innovators

Capital Innovators

Accelerator

Saint Louis, MO

Check: $50K – $1.0M
B2B SAASCONSUMERCLEAN ENERGY+2

Capital Innovators runs top-ranked accelerator programs and manages seed and Series A venture funds focused on technology, consumer products, energy innovations and verticalized corporate accelerator...

Exploring122 portfolio co.

Rockbridge Growth Equity

Rockbridge Growth Equity

VC

Detroit, MO

Check: $7.0M – $7.0M

Rockbridge Growth Equity is a private equity investor. They have a deep industry expertise, the strategic benefits of "sister companies" , a long-term perspective and a different approach to...

Exploring3 portfolio co.

Mariner Capital Ventures

Mariner Capital Ventures

VC

St. Louis, MO

Check: $2.4M – $8.0M

Mariner Capital Ventures (MCV) is a $10 million start-up, angel, and early stage investment fund. MCV targets new and young companies that design innovative and competitive products and services....

Exploring2 portfolio co.

Razorback Capital

Razorback Capital

VC

Kansas City, MO

Check: $380K – $6.0M
Exploring3 portfolio co.

RiverVest

RiverVest

VC

St. Louis, MO

Check: $750K – $46.0M

RiverVest Venture Partners is a venture capital firm focused on identifying and shaping early-stage life science companies to create significant shareholder value. With hands-on, high-level expertise...

Exploring19 portfolio co.

Ascension Ventures

Ascension Ventures

VC

Clayton, MO

Check: $226K – $27.0M

AHV was established in 2001 by Ascension Health with a commitment of $125 million to invest in expansion- to late-stage healthcare companies. Ascension Health is the nation's largest Catholic and...

Exploring18 portfolio co.

Arch Grants

Arch Grants

Corporate

St. Louis, MO

Check: $50K – $110K

Arch Grants is an international business plan competition established to attract entrepreneurs in any field to launch new, innovative businesses in St. Louis. Grant recipients receive up to $50,000,...

Exploring9 portfolio co.

St. Louis Arch Angels

St. Louis Arch Angels

VC

St. Louis, MO

Check: $138K – $8.5M

The mission of the St. Louis Arch Angels is to provide opportunities for their members to obtain outstanding financial returns by investing in early-stage companies with high growth potential in the...

Exploring11 portfolio co.

NIPR

NIPR

VC

Kansas City, MO

Check: $3.7M – $3.9M

National Insurance Producer Registry (NIPR) is a non-profit affiliate of the National Association of Insurance Commissioners (NAIC). NIPR developed and implemented the Producer Database (PDB) and the...

Exploring6 portfolio co.

Kauffman Foundation

Kauffman Foundation

Corporate

Kansas City, MO

Check: $75K – $24.0M

Kaufman foundation focuses on grant making and operations in the fields of education and entrepreneurship.

Exploring7 portfolio co.

Missouri Technology Corporation

Missouri Technology Corporation

VC

Jefferson City, MO

Check: $75K – $835K

The Missouri Technology Corporation is a public-private partnership created by the Missouri General Assembly to promote entrepreneurship and foster the growth of new and emerging high-tech companies....

Exploring5 portfolio co.

Think Big Partners

Think Big Partners

VC

Kansas City, MO

Check: $24K – $2.3M

Think Big Partners is an early-stage startup accelerator and mentorship-based collaborative network located in Kansas City, Missouri. Think Big Partners has successfully launched or grown over 150...

Exploring3 portfolio co.

Oakwood Medical Investors

Oakwood Medical Investors

VC

St. Louis, MO

Check: $2.1M – $30.0M

Oakwood Medical Investors is a life science venture capital fund formed to invest in development stage medical device, biotechnology, pharmaceutical and medical service companies. Target portfolio...

Exploring4 portfolio co.

Prolog Ventures

Prolog Ventures

VC

St. Louis, MO

Check: $500K – $15.3M

Venture capital firm specializing in life sciences. Since launch in 2001, they have supported more than 25 young companies. Prolog invests in traditional healthcare opportunities as well as emerging...

Exploring20 portfolio co.

BioGenerator

BioGenerator

VC

St. Louis, MO

Check: $75K – $4.0M

The BioGenerator, the non-profit venture development organization of BioSTL, facilitates the formation of successful, sustainable bioscience companies in the St. Louis region. It provides start-up...

Exploring31 portfolio co.

Redbud VC

Redbud VC

VC

Missouri

Check: $250K – $400K

Redbud VC invests first or early in technology startups across North America (US & Canada), with a focus on founders "strengthened by struggle." The firm is managed by Willy and Jabbok Schlacks...

Moderately Active7 portfolio co.

Melissa Walker

Graematter

VC

St. Louis, MO

Exploring2 portfolio co.

Centennial Investors

Centennial Investors

Angel

Columbia, MO

Check: $150K – $500K

Centennial Investors is an angel-investing organization based in mid-Missouri. The group provides risk capital to high-potential technology- or science-based startups primarily in Missouri and...

Exploring23 portfolio co.

Daniel Westerheim

Daniel Westerheim

Angel

Columbia, MO

Check: $150K – $500K

Centennial Investors is an angel investing group focused on providing risk capital to high-potential, technology- or science-based startups in Missouri and adjoining states. The group seeks to invest...

Moderately Active17 portfolio co.

Brett Calhoun

Redbud VC

VC

Missouri

Check: $250K – $500K

The greatest driver of venture returns is the selection of founders strengthened by struggle. We seek founders who display extraordinary perseverance, prioritize customer discovery, and are...

Exploring4 portfolio co.

Explore Missouri

About the Missouri Startup Ecosystem

Missouri is home to a thriving startup ecosystem with 27 investors and 1 startups in our directory. Key hubs include St. Louis, Kansas City, Saint Louis.

The most active sectors in Missouri include IOT, LOGISTICS AND SHIPPING, SUPPLY CHAIN TOOLS. 1 investors have made recent investments, showing strong capital deployment activity in the region.

Local investors offer advantages beyond capital — regional network effects, knowledge of local market dynamics, and introductions to customers and partners. Geographic proximity often leads to more engaged board members and advisors.

Frequently Asked Questions

How many investors and startups are in Missouri?
We track 27 investors and 1 startups in Missouri. 1 investors have made recent investments, and 0 startups are generating revenue.
What is the typical check size for investors in Missouri?
The average check size among investors in Missouri is $6.6M. Check sizes vary by investor type — angels typically write smaller checks while VCs and funds invest larger amounts.
How do I connect with investors in Missouri?
Upload your pitch deck on The Founders' Group landing page for a free AI analysis. Our matching algorithm considers sector focus, stage fit, check size, location, and thesis alignment to recommend the most relevant investors for your startup.
What sectors are most popular in Missouri?
The most active sectors in Missouri based on our data include IOT, LOGISTICS_AND_SHIPPING, SUPPLY_CHAIN_TOOLS. However, investors and startups in our directory span all major sectors.
Which cities in Missouri have the most startup activity?
The highest concentration of investors and startups in Missouri is in St. Louis, Kansas City, Saint Louis. These cities have the strongest local ecosystems for fundraising and startup growth.

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